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Violence: Fantasy violence includes some comic fighting (including a bar fight) and some shooting, with gunshot wounds. There are also some threatening characters, an image of the alien eating a bird, and the suggestion of a hurt dog.
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Sex: A nearly constant stream of sexual innuendo, mostly for humorous effect. At a comic convention, the main characters check out several sexy "Princess Leias" (in costume). A drawing of an alien girl with three breasts is referenced several times. A shot of the alien's naked buttocks.
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Language: Near-constant use of "f--k" and "s--t," plus "p---y," "c--k," "c--ksucker," "ass," "son of a bitch," "hell," "t-ts," "pee," "Jesus Christ" (as an exclamation), "butt," "d--k," "prick," "damn," "crap," "goddamn," and an image of a raised middle finger.
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Consumerism: A mention of Reese's Pieces in reference to E.T. Since the movie begins at a comic book convention, there's also a stream of various references to comic books and other sci-fi stuff.
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Drinking, drugs and smoking: The alien smokes both cigarettes and pot; he shares his pot with one character, but it proves too strong, and she passes out. The main characters also drink beer and get drunk.