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Violence: Several moments of violence -- involving fists, guns, knives, and an axe -- pop up so suddenly that they're quite startling. The fights are realistic, bloody, and gory. People are killed, their bodies disposed of. Some characters also use cars as weapons, intentionally ramming into other vehicles.
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Sex: Some scenes show people having sex -- sound effects, but no nudity. The couples are shown talking in bed afterward, presumably naked under the covers. One character builds an elaborate sex chair with an extremely crass sexual accessory, which he shows off to a date.
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Language: Plenty of swearing, including "f--k," "s--t," "bitch," and more. Every character's vocabulary is liberally peppered with curses.
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Consumerism: Some brands of alcohol are referred to by name and/or shown on screen. Several characters' cars are shown repeatedly, including their logos. One fitness-obsessed man is insulted when his fancy bike is described as a "Schwinn." He's also practically glued to his iPod. There are mentions of PCs, Macs, and Gatorade, as well as logos for Safeway, 7-Eleven, and Tropicana.
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Drinking, drugs and smoking: Osborne Cox drinks often, and some scenes show him carefully preparing his beverages. In several scenes, he's clearly drunk. A coworker says Cox has a drinking problem, sending him into a rage.