Two superstar genetic engineers (Brody and Polley) perform genetic experiments splicing human and animal DNA. The result is a female creature named Dren who grows at an accelerated rate.
A government scientist (Kingsley) performs genetic experiments splicing human and alien DNA. The result is a female creature named Sil who grows at an accelerated rate.
Dren starts out as a docile, inquisitive creature with a voracious appetite who matures quickly into a female with a strong desire to have sexy times.
Sil starts out as a docile, inquisitive creature (played by a young Michelle Williams) with a voracious appetite until scientists try to gas her and she escapes and goes on the lam. She matures quickly into Henstridge’s Sil, who has a strong desire to have sexy times.
The Wrath of Dren:
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Dren resents being locked up in a cold barn by Brody and Polley, so she begins to lash out and tries to escape. One casualty of her frustration is a cat, which was given to her as a pet.
The Wrath of Sil:
Sil resents being chased by a government team and hides out in a motel when she’s not on the prowl for a sperm donor. One casualty of her frustration is diabetic and overly amorous clubgoer, whose disease makes him an unsuitable mate.
The Moral of Splice and Species: If you’re in the business of making monsters, don’t be surprised when they scare you.