| Berlin International Film Festival |
Mr. Hobbs Takes a Vacation |
Silver Bear for Best Actor |
1962 |
Winner |
| Hollywood Foreign Press Association |
Mr. Hobbs Takes a Vacation |
Best Performance by an Actor in a Motion Picture - Musical or Comedy |
1962 |
Nominee |
| Academy of Motion Picture Arts and Sciences |
Anatomy of a Murder |
Best Actor |
1959 |
Nominee |
| New York Film Critics Circle |
Anatomy of a Murder |
Best Actor |
1959 |
Winner |
| Venice International Film Festival |
Anatomy of a Murder |
Volpi Cup for Best Actor |
1959 |
Winner |
| Hollywood Foreign Press Association |
Harvey |
Best Performance by an Actor in a Motion Picture - Drama |
1950 |
Nominee |
| Academy of Motion Picture Arts and Sciences |
Harvey |
Best Actor |
1950 |
Nominee |
| Academy of Motion Picture Arts and Sciences |
It's a Wonderful Life |
Best Actor |
1946 |
Nominee |
| Academy of Motion Picture Arts and Sciences |
The Philadelphia Story |
Best Actor |
1940 |
Winner |
| National Board of Review |
The Shop Around the Corner |
Best Acting |
1940 |
Winner |
| Academy of Motion Picture Arts and Sciences |
Mr. Smith Goes to Washington |
Best Actor |
1939 |
Nominee |
| New York Film Critics Circle |
Mr. Smith Goes to Washington |
Best Actor |
1939 |
Winner |